Arizona Diamondbacks vs. Minnesota Twins Prediction, Odds & Key Players: MLB Game Preview for September 12, 2025

Friday, September 12th, 2025

Arizona Diamondbacks vs. Minnesota Twins: Series Opener Preview

The Minnesota Twins will host the Arizona Diamondbacks on Friday night at Target Field, opening a three-game MLB series. Both teams currently sit fourth in their respective divisions, with the Diamondbacks at 73-74 in the NL West and the Twins at 64-82 in the AL Central.

Pitching Probables

The series opener features Brandon Pfaadt (13-8, 5.18 ERA, 1.38 WHIP, 129 strikeouts) on the mound for the Diamondbacks, facing off against Pablo Lopez (5-4, 2.83 ERA, 1.08 WHIP, 65 strikeouts) for the Twins. Oddsmakers list the Twins as -131 favorites, with the Diamondbacks at +110, and an over/under set at 8.5 runs.

Weather

Today's weather at Target Field is comfortable for baseball, with partly cloudy skies, a high near 74°F, and light winds around 7 mph out of the southwest. There is only a 10% chance of precipitation, so conditions should stay dry for the game.

Team Performances and Key Stats

Minnesota enters play with a 35-36 record at home and stands out when hitting the long ball, posting a 32-17 record in games with at least two home runs. Meanwhile, Arizona holds a 35-40 record on the road and boasts major NL power with 199 total home runs, ranking second in the league.

This will be the first matchup of the season between the Diamondbacks and Twins.

Top Performers to Watch

For Minnesota, Byron Buxton has flexed his power with 31 home runs and a strong .568 slugging percentage. Royce Lewis has been productive recently, going 11-for-41 with three home runs and eight RBI over his last 10 games.

On the Arizona side, Geraldo Perdomo stands out with 27 doubles, four triples, 18 home runs, and 93 RBI this season. Ildemaro Vargas has also been hot, hitting 9-for-30 with two homers and 10 RBI in his last 10 games.

Recent Results

The Twins have gone 2-8 over their last 10 games, hitting .247 as a team with a 6.59 ERA, and have been outscored by 22 runs in that span. The Diamondbacks are 5-5 in their last 10, hitting .246 with a 4.40 ERA, and have outscored opponents by one run.

Injuries

Twins: Ryan Jeffers (7-Day IL, head), Alan Roden (60-Day IL, thumb), Christian Vazquez (10-Day IL, shoulder), Anthony Misiewicz (15-Day IL, shoulder), David Festa (15-Day IL, shoulder).

Diamondbacks: Ketel Marte (day-to-day, foot), Tyler Locklear (10-Day IL, elbow), Pavin Smith (60-Day IL, quadricep), Lourdes Gurriel Jr. (10-Day IL, ACL), Kevin Ginkel (60-Day IL, shoulder), Tommy Henry (60-Day IL, elbow), Christian Montes De Oca (60-Day IL, elbow), Justin Martinez (60-Day IL, elbow), Cristian Mena (60-Day IL, shoulder), Corbin Burnes (60-Day IL, elbow), A.J. Puk (60-Day IL, elbow), Blake Walston (60-Day IL, elbow).

In summary

The Minnesota Twins and Arizona Diamondbacks kick off a fresh series with intriguing pitching matchups and power hitters on both sides. With fair weather conditions and both teams looking to make a late-season push, this Friday night contest at Target Field promises competitive baseball between two determined clubs.

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