Baltimore Orioles at Cleveland Guardians Game Preview – July 22, 2025

Tuesday, July 22nd, 2025

Baltimore Orioles (44-55, fifth in the AL East) vs. Cleveland Guardians (49-50, second in the AL Central)

Cleveland; Tuesday, July 22, 2025, 5:40 PM EDT

Pitching Probables

Orioles: Brandon Young (0-4, 7.52 ERA, 1.78 WHIP, 25 strikeouts)

Guardians: Joey Cantillo (1-0, 4.17 ERA, 1.44 WHIP, 54 strikeouts)

Guardians -142, Orioles +119; over/under is 8 1/2 runs

Bottom Line

The Cleveland Guardians bring a 1-0 lead into the latest game of the series against the Baltimore Orioles.

Cleveland is 49-50 overall and 23-24 at home. The Guardians have the eighth-ranked team ERA in the AL at 3.95.

Baltimore has a 44-55 record overall and a 22-30 record in road games. The Orioles have a 26-45 record in games when they have allowed a home run.

Tuesday's game is the fifth meeting between these teams this season. The season series is tied 2-2.

Top Performers

Jose Ramirez has 18 doubles, two triples and 20 home runs while hitting .294 for the Guardians. Angel Martinez is 13 for 42 with five doubles and four home runs over the last 10 games.

Ryan O'Hearn has 14 doubles, 12 home runs and 36 RBI while hitting .278 for the Orioles. Jordan Westburg is 13 for 39 with a double and a home run over the past 10 games.

Last 10 Games

Guardians: 8-2, .229 batting average, 3.77 ERA, outscored opponents by 19 runs

Orioles: 4-6, .235 batting average, 5.63 ERA, outscored by 22 runs

Injuries

Guardians: Paul Sewald: 15-Day IL (shoulder), Lane Thomas: 10-Day IL (foot), Gabriel Arias: 10-Day IL (ankle), Will Brennan: 60-Day IL (forearm), Andrew Walters: 60-Day IL (lat), Ben Lively: 60-Day IL (forearm), Shane Bieber: 60-Day IL (elbow), Trevor Stephan: 60-Day IL (elbow), John Means: 60-Day IL (elbow), Sam Hentges: 60-Day IL (shoulder)

Orioles: Scott Blewett: 15-Day IL (elbow), Jorge Mateo: 60-Day IL (elbow), Gary Sanchez: 10-Day IL (knee), Keegan Akin: 15-Day IL (shoulder), Chadwick Tromp: 10-Day IL (back), Zach Eflin: 15-Day IL (back), Maverick Handley: 7-Day IL (head), Ryan Mountcastle: 60-Day IL (hamstring), Adley Rutschman: 10-Day IL (oblique), Cade Povich: 15-Day IL (hip), Cody Poteet: 60-Day IL (shoulder), Grayson Rodriguez: 60-Day IL (elbow), Albert Suarez: 60-Day IL (shoulder), Tyler Wells: 60-Day IL (elbow), Kyle Bradish: 60-Day IL (elbow)

In summary

The Baltimore Orioles (44-55) will face the Cleveland Guardians (49-50) on Tuesday, July 22, 2025, at 5:40 PM EDT in Cleveland. This marks the fifth matchup between the two teams this season, with the season series currently tied at 2-2, though the Guardians hold a 1-0 lead in the ongoing series. On the mound, the Orioles will send Brandon Young (0-4, 7.52 ERA) against the Guardians' Joey Cantillo (1-0, 4.17 ERA). Recent performance favors Cleveland, who are 8-2 in their last 10 games compared to Baltimore's 4-6. Key offensive contributors include Jose Ramirez for the Guardians and Ryan O'Hearn for the Orioles. The Guardians are favored in this contest with an over/under of 8 1/2 runs.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.