Baltimore Orioles at Cleveland Guardians Game Preview: July 23, 2025 MLB Odds

Wednesday, July 23rd, 2025

Baltimore Orioles at Cleveland Guardians MLB Game Preview

The Baltimore Orioles (44-56, fifth in the AL East) are set to face the Cleveland Guardians (50-50, second in the AL Central) on Wednesday, July 23, 2025, at 5:40 PM EDT in Cleveland.

Pitching Matchup

For the Orioles, Zach Eflin (0-0) is expected to take the mound. The Guardians will counter with Slade Cecconi (5-4, 3.84 ERA, 1.23 WHIP, 58 strikeouts).

Odds and Betting Information

The Cleveland Guardians are favored at -129, with the Baltimore Orioles as underdogs at +109. The over/under for the game is set at 8 1/2 runs.

Game Preview

The Cleveland Guardians, currently enjoying a three-game home winning streak, will host the Baltimore Orioles. Cleveland's overall record stands at 50-50, with a 24-24 record at home. The Guardians have shown power at the plate, going 18-10 in games where they hit two or more home runs.

Baltimore enters the matchup with a 44-56 overall record and a 22-31 road record. The Orioles have found success in games where they prevented home runs, holding an 18-10 record in such contests.

This will be the sixth meeting between the two teams this season, with the Guardians currently leading the season series 3-2.

Top Players to Watch

For the Guardians, Carlos Santana has contributed with seven doubles and 11 home runs. Jose Ramirez has been a hot hitter recently, with nine hits in his last 35 at-bats, including a double, a triple, and five home runs over the last 10 games.

On the Orioles' side, Jackson Holliday boasts 14 doubles, two triples, and 13 home runs. Ramon Laureano has been performing well over the last 10 games, with 11 hits in 35 at-bats, including two doubles and three home runs.

Recent Form

The Guardians have been in strong form, with an 8-2 record over their last 10 games. During this stretch, they have a .231 batting average, a 3.52 ERA, and have outscored opponents by 18 runs.

The Orioles have a 4-6 record in their last 10 games. They have a .232 batting average, a 5.76 ERA, and have been outscored by 24 runs over the same period.

Injury Report

Guardians: Paul Sewald (15-Day IL, shoulder), Lane Thomas (10-Day IL, foot), Gabriel Arias (10-Day IL, ankle), Will Brennan (60-Day IL, forearm), Andrew Walters (60-Day IL, lat), Ben Lively (60-Day IL, forearm), Shane Bieber (60-Day IL, elbow), Trevor Stephan (60-Day IL, elbow), John Means (60-Day IL, elbow), Sam Hentges (60-Day IL, shoulder).

Orioles: Tyler O'Neill (day-to-day, undisclosed), Scott Blewett (15-Day IL, elbow), Jorge Mateo (60-Day IL, elbow), Gary Sanchez (10-Day IL, knee), Keegan Akin (15-Day IL, shoulder), Chadwick Tromp (10-Day IL, back), Zach Eflin (15-Day IL, back), Maverick Handley (7-Day IL, head), Ryan Mountcastle (60-Day IL, hamstring), Adley Rutschman (10-Day IL, oblique), Cade Povich (15-Day IL, hip), Cody Poteet (60-Day IL, shoulder), Grayson Rodriguez (60-Day IL, elbow), Albert Suarez (60-Day IL, shoulder), Tyler Wells (60-Day IL, elbow), Kyle Bradish (60-Day IL, elbow).

In summary

The Baltimore Orioles will visit the Cleveland Guardians on July 23, 2025, for an MLB matchup. The Guardians, with a 50-50 record and a three-game home winning streak, are favored against the 44-56 Orioles. Slade Cecconi is projected to start for Cleveland, while Zach Eflin is listed for Baltimore. Cleveland has been performing better recently with an 8-2 record in their last 10 games, compared to Baltimore's 4-6. Key players to watch include Jose Ramirez and Carlos Santana for Cleveland, and Jackson Holliday and Ramon Laureano for Baltimore. Both teams are dealing with significant injury lists, which could impact game performance. The Guardians currently lead the season series 3-2.

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