Baltimore Orioles at Cleveland Guardians: MLB Game Preview (July 22, 2025)

Tuesday, July 22nd, 2025

Baltimore Orioles at Cleveland Guardians Game Preview (2025-07-22)

The Baltimore Orioles (44-55, fifth in the AL East) are set to face the Cleveland Guardians (49-50, second in the AL Central) in MLB action. This game continues their series in Cleveland, Ohio.

Game Information

The game is scheduled for Tuesday, July 22, 2025, at 6:40 p.m. EDT in Cleveland.

Pitching Matchup

For the Orioles, Brandon Young (0-4, 7.52 ERA, 1.78 WHIP, 25 strikeouts) is projected to start.

The Guardians will counter with Joey Cantillo (1-0, 4.17 ERA, 1.44 WHIP, 54 strikeouts) on the mound.

Betting Odds

The Guardians are favored at -142, while the Orioles are at +119. The over/under for the game is set at 8 1/2 runs.

Team Standings & Performance

The Cleveland Guardians are 49-50 overall and hold a 23-24 record at home. They boast the eighth-ranked team ERA in the AL at 3.95. The Guardians currently hold a 1-0 lead in the current series against the Orioles.

The Baltimore Orioles come into the game with a 44-55 overall record, including a 22-30 record in road games. They have a 26-45 record in games where they have allowed a home run. This marks the fifth meeting between these teams this season, with the season series currently tied 2-2.

Top Performers

For the Guardians, Jose Ramirez leads the offense with 18 doubles, two triples, and 20 home runs, batting .294. Angel Martinez has been hot recently, going 13 for 42 with five doubles and four home runs over the last 10 games.

On the Orioles' side, Ryan O'Hearn has contributed 14 doubles, 12 home runs, and 36 RBI while hitting .278. Jordan Westburg has been performing well, with 13 hits in 39 at-bats, including a double and a home run, over the past 10 games.

Recent Form (Last 10 Games)

The Guardians have been in strong form, with an 8-2 record over their last 10 games. During this period, they've posted a .229 batting average and a 3.77 ERA, outscoring opponents by 19 runs.

The Orioles have struggled recently, holding a 4-6 record in their last 10 outings. They've hit .235 with a 5.63 ERA and have been outscored by 22 runs.

Injury Report

Guardians Injured Players: Paul Sewald (15-Day IL, shoulder), Lane Thomas (10-Day IL, foot), Gabriel Arias (10-Day IL, ankle), Will Brennan (60-Day IL, forearm), Andrew Walters (60-Day IL, lat), Ben Lively (60-Day IL, forearm), Shane Bieber (60-Day IL, elbow), Trevor Stephan (60-Day IL, elbow), John Means (60-Day IL, elbow), Sam Hentges (60-Day IL, shoulder).

Orioles Injured Players: Scott Blewett (15-Day IL, elbow), Jorge Mateo (60-Day IL, elbow), Gary Sanchez (10-Day IL, knee), Keegan Akin (15-Day IL, shoulder), Chadwick Tromp (10-Day IL, back), Zach Eflin (15-Day IL, back), Maverick Handley (7-Day IL, head), Ryan Mountcastle (60-Day IL, hamstring), Adley Rutschman (10-Day IL, oblique), Cade Povich (15-Day IL, hip), Cody Poteet (60-Day IL, shoulder), Grayson Rodriguez (60-Day IL, elbow), Albert Suarez (60-Day IL, shoulder), Tyler Wells (60-Day IL, elbow), Kyle Bradish (60-Day IL, elbow).

In summary

The Baltimore Orioles and Cleveland Guardians are set to play on Tuesday, July 22, 2025, at 6:40 PM EDT in Cleveland. The Guardians, currently 49-50 and second in the AL Central, will pitch Joey Cantillo (1-0, 4.17 ERA) against the Orioles' Brandon Young (0-4, 7.52 ERA). Baltimore holds a 44-55 record, fifth in the AL East. The Guardians have won 8 of their last 10 games, while the Orioles are 4-6. Key performers include Jose Ramirez for Cleveland and Ryan O'Hearn for Baltimore. The Guardians lead the current series 1-0, with the season series tied 2-2 overall.

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