Baltimore Orioles Seek Sixth Straight Win Over Chicago White Sox: Game Preview, Pitching Matchup, Odds for September 17, 2025

Wednesday, September 17th, 2025

Baltimore Orioles vs. Chicago White Sox MLB Game Preview – September 17, 2025

Matchup Overview

The Baltimore Orioles (71-80, fifth in the AL East) head to Rate Field to take on the Chicago White Sox (57-95, fifth in the AL Central) on September 17, 2025, at 1:10 PM local time. Both teams are looking to make an impact as the regular season winds down.

Pitching Probables

For the Orioles, Tyler Wells (1-0, 2.31 ERA, 0.60 WHIP, 10 strikeouts) will take the mound. Opposing him will be the White Sox's Martin Perez (1-5, 3.27 ERA, 1.05 WHIP, 42 strikeouts).

The Orioles are the favorites, with odds at -129, while the White Sox are listed at +108. The over/under is set at 8 runs.

Weather

Today at Rate Field, expect partly cloudy skies with a high near 76°F, making for comfortable baseball conditions. There's little to no chance of precipitation and light winds around 6 mph out of the northeast, minimizing any impact on play. Fans can anticipate an enjoyable, mild evening at the ballpark.

Team Performance and Season Series

Chicago struggles into this contest on a five-game losing streak, with a 32-45 record at home this year. The White Sox have had difficulties when allowing the long ball, posting a 30-74 record in games where they have allowed a home run.

The Orioles come to Chicago with a 35-42 road record and are 39-65 in games where they've allowed opponents to homer.

This is the sixth meeting between the teams in 2025, with Baltimore leading the season series 5-0.

Players to Watch

Andrew Benintendi has been a consistent force for Chicago, hitting .240 with 16 doubles, two triples, 20 home runs, and 62 RBI. Chase Meidroth has been hot recently, recording 14 hits in his last 33 at-bats including a home run over the past 10 games.

For the Orioles, Jackson Holliday leads with 17 home runs and a .394 slugging percentage. Ryan Mountcastle has contributed with 9 hits, a double, and two RBI in his last 40 at-bats.

Recent Form

The White Sox have gone 3-7 in their last 10 games, producing a .198 batting average and a 4.29 ERA, and have been outscored by 11 runs. The Orioles are 6-4 over their last 10, batting .210 with a 3.99 ERA, but have been outscored by 10 runs.

Injury Report

White Sox: Bryan Hudson (back), Luis Robert (hamstring), Elvis Peguero (elbow), Owen White (hip), Prelander Berroa (elbow), Ky Bush (elbow), Miguel Castro (knee), Drew Thorpe (elbow) are all on the IL.

Orioles: Albert Suarez (elbow), Shawn Dubin (elbow), Trevor Rogers (toe, day-to-day), Brandon Young (hamstring), Scott Blewett (elbow), Gary Sanchez (knee), Felix Bautista (shoulder), Adley Rutschman (oblique), Zach Eflin (back), Colin Selby (hamstring), Grayson Rodriguez (elbow) are out.

In summary

The Baltimore Orioles and Chicago White Sox will face off at Rate Field, with the Orioles looking to maintain their unbeaten record in the season series. Both teams have faced struggles, but strong individual performances and favorable weather conditions set the stage for an exciting matchup. With key injuries on both sides and pitching matchups favoring solid arms, this contest promises an intriguing battle as the 2025 MLB season enters its final stretch.

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