Chicago White Sox Look to End Skid Against Baltimore Orioles: Game Preview, Odds, and Pitching Matchup – September 16, 2025

Tuesday, September 16th, 2025

Baltimore Orioles at Chicago White Sox: Game Preview

The Baltimore Orioles (70-80, fifth in the AL East) are set to take on the Chicago White Sox (57-94, fifth in the AL Central) in an AL matchup at Guaranteed Rate Field. The game is scheduled for 6:40PM local time, with both teams looking to improve their standing late in the season.

Pitching Probables

The Orioles will send Dean Kremer (9-10, 4.43 ERA, 1.26 WHIP, 132 strikeouts) to the mound, while the White Sox counter with Shane Smith (6-7, 3.78 ERA, 1.18 WHIP, 122 strikeouts). Kremer’s durability and strikeout ability will be tested against a Chicago lineup eager to snap a four-game losing streak.

Weather

At Rate Field today, expect mild baseball weather with temperatures in the low 70s, mostly clear skies, and no chance of precipitation. Light winds around 7 mph from the southwest should have minimal impact on play, making for ideal conditions for both hitters and fielders.

Series Outlook

This contest marks the fifth matchup between these clubs this season, with the Orioles currently holding a 4-0 advantage in the season series. Chicago, with a 32-44 record at home, looks to reverse its fortunes and leverage home-field advantage against Baltimore’s squad, who bring a 34-42 road record into this game.

Keys to the Game

The White Sox will seek to rebound, building on their 40-20 record when out-hitting opponents. Meanwhile, the Orioles will aim to tighten their pitching, as they've struggled with a 38-65 record in games where they've surrendered a home run.

Top Performers

Lenyn Sosa leads the White Sox with a .260 batting average, adding 18 doubles, a triple, 20 home runs, 18 walks, and 68 RBIs. Chase Meidroth has gone 13 for 32, with a home run and two RBIs over his last 10 games.

For the Orioles, Colton Cowser brings 12 doubles, 15 home runs, and 38 RBIs to the matchup, while Coby Mayo is 7 for 32 with three home runs in his last 10 appearances.

Recent Form

Over their past 10 games, the White Sox are 4-6 with a .207 team batting average, a 3.98 ERA, and have been outscored by eight runs. The Orioles have won six of their last 10, batting .190 with a 3.39 ERA, while being outscored by 10 runs.

Injury Report

White Sox: Brooks Baldwin (hip), Grant Taylor (groin) are day-to-day. Bryan Hudson (back), Luis Robert (hamstring), Elvis Peguero (elbow), Owen White (hip) are on the 15-Day IL. Prelander Berroa (elbow), Ky Bush (elbow), Miguel Castro (knee), Drew Thorpe (elbow) are on the 60-Day IL.
Orioles: Albert Suarez (elbow), Shawn Dubin (elbow), Trevor Rogers (toe, day-to-day), Dean Kremer (forearm, day-to-day), Brandon Young (hamstring), Scott Blewett (elbow), Gary Sanchez (knee), Jordan Westburg (ankle), Felix Bautista (shoulder), Zach Eflin (back), Colin Selby (hamstring), Grayson Rodriguez (elbow) are all on the IL in various capacities.

In summary

The Baltimore Orioles look to extend their season series lead over the Chicago White Sox in a matchup featuring strong pitching and top offensive contributors. With both teams battling late-season injuries and vying for momentum, expect an exciting game in ideal baseball conditions at Guaranteed Rate Field.

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