Cincinnati Reds at St. Louis Cardinals - June 21, 2025 MLB Preview

Saturday, June 21st, 2025

The Cincinnati Reds (39-37, fourth in the NL Central) face the St. Louis Cardinals (41-35, third in the NL Central) at Busch Stadium on June 21, 2025, at 1:15 PM.

Pitching Probables

Reds: Brent Suter (1-0, 2.91 ERA, 1.12 WHIP, 21 strikeouts)

Cardinals: Sonny Gray (7-2, 3.84 ERA, 1.18 WHIP, 85 strikeouts)

Betting Odds

Cardinals -195, Reds +162; over/under is 9 runs

Game Details

St. Louis has a 41-35 record overall and a 23-14 record in home games. Cardinals pitchers have a collective 3.94 ERA, which ranks 10th in the NL.

Cincinnati has gone 19-20 on the road and 39-37 overall. The Reds have the ninth-ranked team ERA in the NL at 3.91.

Season Series

The matchup Saturday is the sixth time these teams square off this season. The Cardinals hold a 3-2 advantage in the season series.

Top Performers

Willson Contreras leads the Cardinals with 10 home runs while slugging .423. Alec Burleson is 16 for 42 with three doubles, two home runs and seven RBI over the past 10 games.

Elly De La Cruz leads the Reds with 16 home runs while slugging .478. TJ Friedl is 11 for 40 with three home runs and six RBI over the past 10 games.

Last 10 Games

Cardinals: 5-5, .254 batting average, 4.40 ERA, outscored opponents by nine runs

Reds: 6-4, .266 batting average, 5.25 ERA, outscored by six runs

Injuries

Cardinals: Ivan Herrera: 10-Day IL (hamstring), Zack Thompson: 60-Day IL (lat)

Reds: Wade Miley: 15-Day IL (flexor), Graham Ashcraft: 15-Day IL (groin), Rhett Lowder: 60-Day IL (forearm), Hunter Greene: 15-Day IL (groin), Austin Hays: 10-Day IL (foot), Carson Spiers: 60-Day IL (shoulder), Tyler Callihan: 60-Day IL (forearm), Noelvi Marte: 10-Day IL (side), Jeimer Candelario: 10-Day IL (back), Brandon Williamson: 60-Day IL (elbow), Julian Aguiar: 60-Day IL (elbow)

In summary

The St. Louis Cardinals host the Cincinnati Reds on June 21, 2025, at 1:15 PM. The Cardinals are favored with Sonny Gray pitching against the Reds' Brent Suter. St. Louis holds a 3-2 season series advantage and has a better home record than Cincinnati's road record. Key players include Willson Contreras and Alec Burleson for the Cardinals and Elly De La Cruz and TJ Friedl for the Reds. Both teams have several players on the injured list. The Cardinals have performed slightly better in their last 10 games with a 5-5 record compared to the Reds' 6-4 record, but the Reds have a higher batting average over that span.

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