Cincinnati Reds vs. Arizona Diamondbacks: Preview, Odds, and Key Players for August 22, 2025 Matchup

Friday, August 22nd, 2025

Cincinnati Reds vs. Arizona Diamondbacks: Friday Night Showdown at Chase Field

The Cincinnati Reds (67-61) travel to Phoenix to face the Arizona Diamondbacks (62-66) in an exciting National League matchup on Friday night. With both teams holding third place in their respective divisions, this series opener is crucial for postseason aspirations.

Pitching Matchup

The Reds will send Zack Littell (9-8, 3.52 ERA, 1.11 WHIP, 103 strikeouts) to the mound, facing off against Diamondbacks right-hander Ryne Nelson (6-3, 3.58 ERA, 1.07 WHIP, 99 strikeouts). With the over/under set at nine runs, a competitive pitching duel is anticipated.

Team Insights

Arizona boasts a 32-31 home record and is 62-66 overall this season. The Diamondbacks excel in games where they avoid allowing home runs, holding a 28-13 record in those matchups. Meanwhile, Cincinnati is 31-32 on the road and 67-61 overall. The Reds are especially tough when they out-hit their opponents, posting a strong 56-11 record in such contests.

This game marks the fourth meeting between these two teams this season.

Top Performers

For Arizona, Geraldo Perdomo leads the way with 26 doubles, three triples, 13 home runs, and a .287 batting average. Lourdes Gurriel Jr. has been swinging a hot bat recently, collecting three homers and a double over his last 10 games.

Cincinnati's offense is powered by Spencer Steer, who has 17 doubles, two triples, 15 home runs, and 59 RBI. Noelvi Marte is showing great form, hitting three doubles and three home runs in his last 43 at-bats.

Recent Results

In their last 10 games, the Diamondbacks are 5-5, batting .254 with a 4.49 ERA and have outscored opponents by three runs. The Reds are 6-4 over their last 10, with an impressive .276 batting average, a 2.93 ERA, and an 18-run advantage over their opponents.

Injury Report

Arizona will be without several key players, including Anthony DeSclafani (thumb), Kevin Ginkel (shoulder), Gabriel Moreno (hand), Tommy Henry (elbow), Ryan Thompson (scapular strain), Christian Montes De Oca (elbow), Related Links

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