Cincinnati Reds vs. St. Louis Cardinals: Preview, Predictions, and Pitching Matchup for September 16, 2025

Tuesday, September 16th, 2025

Cincinnati Reds at St. Louis Cardinals Game Preview

The Cincinnati Reds (75-75, third place in the NL Central) travel to take on the St. Louis Cardinals (73-78, fourth in the NL Central) at Busch Stadium on Tuesday, September 16, 2025, with first pitch scheduled for 6:45PM.

Weather

Today at Busch Stadium, expect mild baseball weather with a high near 75°F under mostly sunny skies. There’s minimal chance of precipitation, ensuring a dry game. Winds will be light from the southwest at 6–10 mph, creating ideal playing conditions with just a gentle breeze in the outfield.

Pitching Matchup

For Cincinnati, Andrew Abbott (9-6, 2.79 ERA, 1.13 WHIP, 136 strikeouts) will start on the mound. The Cardinals counter with Michael McGreevy (6-3, 4.44 ERA, 1.23 WHIP, 47 strikeouts). The Reds are favored at -115, while the Cardinals are -104; the over/under is set at 8 runs.

Series Overview

The Reds lead the current three-game series 1-0 after securing the first win. This marks the 12th meeting between these division rivals this season, with the Cardinals ahead 6-5 in the season series.

Team Performance

St. Louis owns a 41-35 record at home and is 73-78 overall. The Cardinals have excelled at the plate when hot, posting a 50-15 record in games when they score five or more runs.

Cincinnati comes in at 75-75 overall and holds a 35-41 record on the road. Reds pitchers have been reliable with a team ERA of 4.00, ranking seventh-best in the National League.

Top Performers

Willson Contreras leads the Cardinals with 20 home runs and a slugging percentage of .447. Ivan Herrera has been a key contributor recently, registering 11 hits in his last 39 at bats, including three home runs and five RBI over the past 10 games.

For the Reds, Elly De La Cruz stands out with 30 doubles, seven triples, and 19 home runs while hitting .263. Sal Stewart has been hot, going 10-for-34 with four home runs in his last 10 games.

Recent Results

In their last 10 games, the Cardinals are 3-7, hitting .224 with a 4.99 ERA and having been outscored by 21 runs. The Reds are 5-5 over the same span, batting .219 with a 4.44 ERA and a run differential of minus two.

Injury Report

Cardinals: Willson Contreras (day-to-day, biceps), Masyn Winn (10-Day IL, meniscus), Zack Thompson (60-Day IL, lat).

Reds: Spencer Steer (day-to-day, neck), Ian Gibaut (60-Day IL, shoulder), Wade Miley (60-Day IL, flexor), Rhett Lowder (60-Day IL, forearm), Carson Spiers (60-Day IL, shoulder), Tyler Callihan (60-Day IL, forearm), Brandon Williamson (60-Day IL, elbow), Julian Aguiar (60-Day IL, elbow).

In summary

The Cincinnati Reds and St. Louis Cardinals face off in a pivotal late-season NL Central matchup at Busch Stadium. Both teams are looking to make a push in the standings, with solid pitching matchups and key players returning to form. With ideal weather on tap and both clubs eyeing every advantage, fans can expect a competitive and exciting game as the Reds aim to extend their lead in the series while the Cardinals look to pull even at home.

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