Houston Astros at Arizona Diamondbacks: Game 2 Preview & Odds (July 22, 2025)

Tuesday, July 22nd, 2025

Get ready for an exciting MLB matchup as the Houston Astros face the Arizona Diamondbacks on Tuesday, July 22, 2025, at 8:40 PM.

Game Preview: Houston Astros vs. Arizona Diamondbacks

The Houston Astros (58-42, first in the AL West) will take on the Arizona Diamondbacks (50-51, fourth in the NL West) in Phoenix. The Astros currently lead the series 1-0.

This matchup on Tuesday marks the second meeting between these two teams this season.

Arizona Diamondbacks Overview

Arizona holds a 50-51 overall record and a 26-26 record when playing at home. The Diamondbacks are strong offensively in the National League, ranking third with 146 total home runs, averaging 1.4 per game.

Houston Astros Overview

The Houston Astros come into this game with a 58-42 overall record, including a 25-23 road record. The Astros boast the fifth-ranked team on-base percentage in the American League at .323.

Pitching Matchup

Leading the mound for the Astros will be Framber Valdez, who holds a 10-4 record with a 2.75 ERA, 1.12 WHIP, and 125 strikeouts. For the Diamondbacks, Eduardo Rodriguez is set to pitch, with a record of 3-6, a 5.94 ERA, 1.67 WHIP, and 90 strikeouts.

Betting Odds

The Houston Astros are favored at -126, while the Arizona Diamondbacks are the underdog at +105. The over/under for the game is set at 8 1/2 runs.

Top Performers

For the Diamondbacks, Geraldo Perdomo has been a standout, hitting .270 with 10 home runs, 59 walks, and 72 RBI. Corbin Carroll has also been performing well recently, with 12 hits, three doubles, four triples, a home run, and five RBI over the past 10 games.

Christian Walker has contributed 13 doubles, a triple, 13 home runs, and 51 RBI for the Astros. Yainer Diaz has also shown power in the last 10 games, with eight hits, a double, and three home runs over that span.

Recent Performance

In their last 10 games, the Diamondbacks have a 5-5 record, with a .254 batting average and a 3.87 ERA, outscoring opponents by 14 runs.

The Astros have struggled recently, holding a 3-7 record in their last 10 games, with a .234 batting average and a 4.83 ERA, being outscored by 10 runs.

Injuries

Diamondbacks Injuries:

Gabriel Moreno: 60-Day IL (hand), Jalen Beeks: 15-Day IL (back), Shelby Miller: 15-Day IL (forearm), Tommy Henry: 60-Day IL (elbow), Pavin Smith: 10-Day IL (oblique), Ryan Thompson: 15-Day IL (scapular strain), Ildemaro Vargas: 10-Day IL (foot), Christian Montes De Oca: 60-Day IL (elbow), Justin Martinez: 60-Day IL (elbow), Cristian Mena: 60-Day IL (shoulder), Corbin Burnes: 60-Day IL (elbow), A.J. Puk: 60-Day IL (elbow), Jordan Montgomery: 60-Day IL (elbow), Blake Walston: 60-Day IL (elbow)

Astros Injuries:

Brendan Rodgers: 60-Day IL (oblique), Isaac Paredes: 10-Day IL (hamstring), Jake Meyers: 10-Day IL (calf), Zach Dezenzo: 60-Day IL (hand), Yordan Alvarez: 60-Day IL (hand), Luis Guillorme: 10-Day IL (hamstring), Jeremy Pena: 10-Day IL (rib), Jacob Melton: 10-Day IL (ankle), Shawn Dubin: 15-Day IL (forearm), Pedro Leon: 60-Day IL (knee), Spencer Arrighetti: 60-Day IL (thumb), Ronel Blanco: 60-Day IL (elbow), Hayden Wesneski: 60-Day IL (elbow), Luis Garcia: 60-Day IL (elbow), Cristian Javier: 60-Day IL (elbow), J.P. France: 60-Day IL (shoulder)

In summary

This MLB game preview details the Houston Astros vs. Arizona Diamondbacks matchup on July 22, 2025. The Astros, leading their division, face the Diamondbacks who are looking to improve their standing. Key aspects include the pitching duel between Framber Valdez (Astros) and Eduardo Rodriguez (Diamondbacks), current betting odds favoring Houston, recent team performance trends, and important injury updates for both squads. The Astros hold a 1-0 series lead coming into this second meeting of the season.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.