Houston Astros vs. Arizona Diamondbacks: July 22, 2025 MLB Picks & Odds

Tuesday, July 22nd, 2025

Houston Astros (58-42, first in the AL West) vs. Arizona Diamondbacks (50-51, fourth in the NL West)

Phoenix; Tuesday, 9:40 p.m. EDT

PITCHING PROBABLES

Astros: Framber Valdez (10-4, 2.75 ERA, 1.12 WHIP, 125 strikeouts)

Diamondbacks: Eduardo Rodriguez (3-6, 5.94 ERA, 1.67 WHIP, 90 strikeouts)

Astros -126, Diamondbacks +105; over/under is 8 1/2 runs

BOTTOM LINE

The Houston Astros meet the Arizona Diamondbacks with a 1-0 series lead.

Arizona has a 50-51 record overall and a 26-26 record at home. The Diamondbacks rank third in the NL with 146 total home runs, averaging 1.4 per game.

Houston is 25-23 on the road and 58-42 overall. The Astros have the fifth-ranked team on-base percentage in the AL at .323.

The matchup Tuesday is the second meeting between these teams this season.

TOP PERFORMERS

Geraldo Perdomo has 10 home runs, 59 walks and 72 RBI while hitting .270 for the Diamondbacks. Corbin Carroll is 12 for 45 with three doubles, four triples, a home run and five RBI over the past 10 games.

Christian Walker has 13 doubles, a triple, 13 home runs and 51 RBI for the Astros. Yainer Diaz is 8 for 41 with a double and three home runs over the last 10 games.

LAST 10 GAMES

Diamondbacks: 5-5, .254 batting average, 3.87 ERA, outscored opponents by 14 runs

Astros: 3-7, .234 batting average, 4.83 ERA, outscored by 10 runs

INJURIES

Diamondbacks: Gabriel Moreno: 60-Day IL (hand), Jalen Beeks: 15-Day IL (back), Shelby Miller: 15-Day IL (forearm), Tommy Henry: 60-Day IL (elbow), Pavin Smith: 10-Day IL (oblique), Ryan Thompson: 15-Day IL (scapular strain), Ildemaro Vargas: 10-Day IL (foot), Christian Montes De Oca: 60-Day IL (elbow), Justin Martinez: 60-Day IL (elbow), Cristian Mena: 60-Day IL (shoulder), Corbin Burnes: 60-Day IL (elbow), A.J. Puk: 60-Day IL (elbow), Jordan Montgomery: 60-Day IL (elbow), Blake Walston: 60-Day IL (elbow)

Astros: Brendan Rodgers: 60-Day IL (oblique), Isaac Paredes: 10-Day IL (hamstring), Jake Meyers: 10-Day IL (calf), Zach Dezenzo: 60-Day IL (hand), Yordan Alvarez: 60-Day IL (hand), Luis Guillorme: 10-Day IL (hamstring), Jeremy Pena: 10-Day IL (rib), Jacob Melton: 10-Day IL (ankle), Shawn Dubin: 15-Day IL (forearm), Pedro Leon: 60-Day IL (knee), Spencer Arrighetti: 60-Day IL (thumb), Ronel Blanco: 60-Day IL (elbow), Hayden Wesneski: 60-Day IL (elbow), Luis Garcia: 60-Day IL (elbow), Cristian Javier: 60-Day IL (elbow), J.P. France: 60-Day IL (shoulder)

In summary

The Houston Astros (58-42, first in AL West) will face the Arizona Diamondbacks (50-51, fourth in NL West) in Phoenix on Tuesday at 9:40 p.m. EDT. The Astros hold a 1-0 series lead in this second meeting of the season. Framber Valdez (10-4, 2.75 ERA) is scheduled to pitch for Houston against Eduardo Rodriguez (3-6, 5.94 ERA) for Arizona. The Astros are favored at -126, with the over/under set at 8 1/2 runs. Recent performance shows the Diamondbacks with a 5-5 record in their last 10 games, while the Astros are 3-7. Key offensive contributors include Geraldo Perdomo and Corbin Carroll for Arizona, and Christian Walker and Yainer Diaz for Houston. Both teams are navigating extensive injury lists.

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