Houston Astros vs. Los Angeles Angels Prediction, Odds & Key Players for September 26, 2025 Showdown in Anaheim

Friday, September 26th, 2025

Houston Astros vs. Los Angeles Angels: Game Preview

The Houston Astros (85-74, second in the AL West) are set to face the Los Angeles Angels (71-88, fifth in the AL West) at Angel Stadium to kick off a three-game weekend series.

Pitching Matchup

On the mound for Houston will be Jason Alexander (4-2, 4.83 ERA, 1.39 WHIP, 61 strikeouts). He will be countered by Kyle Hendricks (8-10, 4.79 ERA, 1.28 WHIP, 106 strikeouts) for the Angels.

Betting odds currently have the Astros favored at -150, the Angels at +125, with an over/under set at 9 runs.

Team Performance Overview

Los Angeles enters the series with a home record of 38-40 and an overall record of 71-88. The Angels have shown strong offense in games where they score five or more runs, boasting a 44-14 record in those matchups.

Houston has posted a 39-39 record on the road and stands at 85-74 overall. The Astros are especially dominant when their offense is firing, sporting a 53-7 record when reaching the five-run mark.

This will be the 11th matchup between the two teams this season, with Houston holding a 6-4 advantage in the season series.

Top Performers

For the Angels, Nolan Schanuel leads with 23 doubles, a triple, 12 home runs, and 53 RBI. Taylor Ward is swinging a hot bat, going 11 for 39 with six home runs over the last 10 games.

On the Astros’ side, Yainer Diaz has delivered 23 doubles, a triple, and 19 home runs this season. Jeremy Pena is 13 for 42 with four doubles and two home runs in his last 10 games.

Recent Trends

The Angels have struggled recently, with a 2-8 record over their last 10 games, hitting .184 as a team with a 6.54 ERA and being outscored by 34 runs.

The Astros have posted a 4-6 record in their past 10, batting .218 with a 4.97 ERA and being outscored by 12 runs.

Injuries

Angels

Yusei Kikuchi (day-to-day, forearm), Robert Stephenson (15-Day IL, elbow), Jose Soriano (15-Day IL, ribs), Zach Neto (10-Day IL, hand), Reid Detmers (60-Day IL, elbow), Travis d'Arnaud (7-Day IL, head), Andrew Chafin (15-Day IL, tricep), Jorge Soler (60-Day IL, back), Victor Mederos (60-Day IL, shoulder), Carson Fulmer (60-Day IL, elbow), Gustavo Campero (60-Day IL, ankle), Tyler Anderson (15-Day IL, oblique), Hunter Strickland (60-Day IL, shoulder), Ben Joyce (60-Day IL, shoulder), Anthony Rendon (60-Day IL, hip)

Astros

Jeremy Pena (day-to-day, oblique), Kaleb Ort (60-Day IL, elbow), Yordan Alvarez (10-Day IL, ankle), Lance McCullers (15-Day IL, hand), Luis Garcia (60-Day IL, elbow), Spencer Arrighetti (15-Day IL, elbow), John Rooney (60-Day IL, concussion/nasal), Brendan Rodgers (60-Day IL, oblique), Pedro Leon (60-Day IL, knee), Brandon Walter (60-Day IL, elbow), Bennett Sousa (15-Day IL, elbow), Josh Hader (15-Day IL, shoulder), Zach Dezenzo (60-Day IL, hand), Ronel Blanco (60-Day IL, elbow), Hayden Wesneski (60-Day IL, elbow)

Weather

At Angel Stadium today, expect pleasant baseball weather with mostly sunny skies and a high near 78°F. There’s little chance of precipitation, and winds will be light at 6-8 mph out of the southwest, making for ideal playing conditions.

In summary

The Houston Astros and Los Angeles Angels meet for their 11th matchup of the season, launching a key three-game series in Anaheim. Both teams are dealing with injuries and looking to improve on recent struggles. Houston holds the edge in the season series and comes in with the favored odds. Fans can look forward to an exciting matchup in perfect Southern California weather as both teams look to finish their seasons strong.

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