Pittsburgh Pirates vs. Cincinnati Reds Preview: Lineups, Pitching Matchup, Odds & Prediction for September 23, 2025

Tuesday, September 23rd, 2025

Pittsburgh Pirates vs. Cincinnati Reds: MLB Showdown at Great American Ball Park

The Pittsburgh Pirates (67-89, fifth in the NL Central) are set to face off against the Cincinnati Reds (80-76, third in the NL Central) at Great American Ball Park on Tuesday at 6:40 p.m. EDT.

Pitching Probables

The Pirates will send Johan Oviedo to the mound. Oviedo boasts a 2-0 record with a 3.52 ERA, 1.24 WHIP, and 32 strikeouts this season. For the Reds, Brady Singer will start, entering the game with a 14-10 record, a 3.86 ERA, a 1.22 WHIP, and 155 strikeouts.

Betting Odds

The Reds are favored at -155 while the Pirates are listed at +130. The over/under for the game is set at 8.5 runs.

Game Overview

The Cincinnati Reds return home after a standout performance by Joey Bart, who delivered four hits in his last game. With a home record of 44-34, the Reds have a strong track record in Cincinnati and have hit 161 home runs this season, ranking ninth in the National League.

The Pirates have struggled on the road this year with a 23-52 record, but they have managed a 17-11 record in contests where they hit at least two home runs. This will be the 11th matchup between these NL Central foes in the 2025 season, with the Reds currently leading the series 6-4.

Top Performers

For Cincinnati, Gavin Lux stands out with a .267 batting average, supported by 26 doubles, two triples, five home runs, 55 walks, and 51 RBI. Austin Hays has also been productive recently, going 10 for 36 in his last 10 games.

The Pirates feature Bryan Reynolds, who leads the team with a .244 average, 36 doubles, three triples, and 16 home runs. Jared Triolo has also shown promise, recording 14 hits in his last 44 at-bats with two homers and four RBI over 10 games.

Recent Performance

In their last 10 games, the Reds have posted a 6-4 record with a .225 batting average and a 3.98 team ERA, outscoring opponents by two runs. The Pirates are 3-7 in their last 10, hitting .231 with an impressive 3.10 ERA, and have also outscored opponents by two runs across those games.

Injury Report

Cincinnati Reds

Austin Hays: day-to-day (back)
Ian Gibaut: 60-Day IL (shoulder)
Wade Miley: 60-Day IL (flexor)
Carson Spiers: 60-Day IL (shoulder)
Tyler Callihan: 60-Day IL (forearm)
Brandon Williamson: 60-Day IL (elbow)
Julian Aguiar: 60-Day IL (elbow)

Pittsburgh Pirates

Ronny Simon: 10-Day IL (shoulder)
Endy Rodriguez: 60-Day IL (elbow)
Enmanuel Valdez: 60-Day IL (shoulder)
Jared Jones: 60-Day IL (elbow)

Weather

Today at Great American Ball Park, expect pleasant baseball weather with temperatures in the upper 70s, mostly clear skies, and no significant chance of precipitation. Winds will be light out of the southwest at 6-8 mph, creating ideal conditions for both pitchers and hitters.

In summary

Tuesday's matchup between the Pittsburgh Pirates and the Cincinnati Reds features two NL Central rivals with much at stake as the season nears its conclusion. With excellent weather and strong starting pitching expected, both teams will look to capitalize on recent standouts and key performances. The Reds seek to strengthen their hold on the season series, while the Pirates aim to play spoiler and improve their road record. Expect an exciting contest under optimal baseball conditions in Cincinnati.

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