Pittsburgh Pirates vs. Cincinnati Reds: Preview, Odds, and Pitching Matchup for September 24, 2025

Wednesday, September 24th, 2025

Pittsburgh Pirates vs. Cincinnati Reds: Game Preview

The Pittsburgh Pirates will head to Cincinnati to face the Reds in what promises to be an exciting matchup at Great American Ball Park. The Pirates, who currently hold a 68-89 record and sit fifth in the NL Central, are aiming to extend their three-game win streak. Meanwhile, the Reds, with an 80-77 record and third place in the division, are looking to solidify their hold in the standings.

Pitching Matchup

The game features a compelling pitching duel. The Pirates will send Paul Skenes (10-10, 2.03 ERA, 0.96 WHIP, 209 strikeouts) to the mound. The Reds counter with Hunter Greene (7-4, 2.74 ERA, 0.93 WHIP, 125 strikeouts), setting the stage for a low-scoring contest, reflected by the over/under line set at 7 runs. Cincinnati enters as slight favorites at -120 odds, while the Pirates are at +100.

Weather

Today at Great American Ball Park, expect pleasant baseball weather with temperatures around 74°F under mostly sunny skies. There's little to no chance of precipitation, and a light breeze from the southwest at 7 mph should have minimal impact on play. Overall, ideal conditions for both fans and players.

Season Series

This marks the 12th meeting between the two clubs this season, with the Reds holding a narrow 6-5 advantage in the series. Both teams have demonstrated competitive play throughout their matchups.

Team Performance

Cincinnati has been strong at home with a 44-35 record and have excelled in games where they record at least eight hits, going 57-33 in such contests. The Pirates have struggled on the road with a 24-52 record but have showcased solid pitching, holding a collective 3.82 ERA, which ranks seventh in the majors.

Top Performers

For the Reds, Elly De La Cruz has filled the stat sheet with 31 doubles, seven triples, and 21 home runs this season. Sal Stewart has been hot recently, going 9-for-31 with a double, three home runs, and four RBI over the last 10 games.

The Pirates have relied on Bryan Reynolds, who has contributed 36 doubles, three triples, 16 home runs, and 73 RBI. Jared Triolo has also impressed recently, posting a 13-for-44 tally with three doubles, two home runs, and four RBI in his last 10 games.

Recent Form

In their last 10 games, the Reds have gone 6-4 with a .224 team batting average and a 4.03 ERA, outscoring opponents by three runs. The Pirates are 4-6 in their last 10, batting .227 with an excellent team ERA of 2.97, and have actually outscored their opponents by five runs during that stretch.

Injuries

The Reds are dealing with several injuries: Rhett Lowder (forearm), Ian Gibaut (shoulder), Wade Miley (flexor), Carson Spiers (shoulder), Tyler Callihan (forearm), Brandon Williamson (elbow), and Julian Aguiar (elbow) are all on the 60-day IL. Austin Hays is day-to-day with a back issue.

For Pittsburgh, Joey Bart is day-to-day with a wrist injury. Ronny Simon (shoulder), Endy Rodriguez (elbow), Enmanuel Valdez (shoulder), and Jared Jones (elbow) are all on the 60-day IL.

In summary

The Pittsburgh Pirates look to add to their current win streak as they take on the Cincinnati Reds in Cincinnati. With ideal weather conditions at Great American Ball Park, a promising pitching matchup between Paul Skenes and Hunter Greene, and both teams fighting for momentum late in the season, this NL Central clash is set to deliver excitement for baseball fans and bettors alike. Keep an eye on standout performers and pitching as these division rivals battle for supremacy in their season series.

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