San Diego Padres vs. Arizona Diamondbacks: MLB Showdown Preview, Odds & Key Players – September 28, 2025

Sunday, September 28th, 2025

Arizona Diamondbacks at San Diego Padres: Game Preview and Analysis

The Arizona Diamondbacks (80-81, third in the NL West) face off against the San Diego Padres (89-72, second in the NL West) at Petco Park on September 28, 2025, at 2:10 PM local time. This matchup marks the 13th meeting between the two National League West rivals this season, with the Padres holding a 7-5 advantage in the season series.

Pitching Matchup

The Diamondbacks will send Brandon Pfaadt (13-8, 5.00 ERA, 1.33 WHIP, 142 strikeouts) to the mound as he looks to end Arizona's four-game losing skid. The Padres counter with JP Sears (0-0), who will be aiming for a strong finish to the season.

Weather

Today at Petco Park, expect mostly sunny skies with temperatures around 75°F, ideal for baseball. There's no significant chance of precipitation, and light winds from the west at 7 mph should have minimal impact on gameplay. Conditions are excellent for fans and players alike.

Game Insights

San Diego enters with a strong 51-29 home record and has excelled in games where their offense outpaces opponents, going 71-19 when collecting more hits. On the other side, Arizona posts a 37-43 road record and a similar trend, going 61-13 when they outhit opponents. Both teams are looking to finish their regular seasons on a high note as the postseason approaches.

Top Performers

San Diego Padres

Fernando Tatis Jr. drives the Padres’ lineup with 27 doubles, two triples, and 25 home runs on the season. Luis Arraez has caught fire recently, batting 15 for 39 with a double and a home run over the Padres’ last 10 games.

Arizona Diamondbacks

Geraldo Perdomo leads Arizona with a .291 batting average and contributes across the board: 33 doubles, five triples, 20 home runs, 94 walks, and 99 RBI. Ketel Marte has been reliable as well, going 14 for 44 with two homers and six RBI in his last 10 games.

Recent Performance

San Diego Padres

The Padres have gone 7-3 in their last 10 games, hitting .258 as a team and posting a solid 3.00 ERA while outscoring their opponents by 15 runs.

Arizona Diamondbacks

Arizona is 4-6 over their past 10 contests, with a .256 team batting average and a 4.50 ERA, being outscored by 16 runs during that stretch.

Injury Report

San Diego Padres

- Ramon Laureano: 10-Day IL (finger)
- Nestor Cortes: 15-Day IL (elbow)
- Jason Adam: 15-Day IL (quadricep)
- Jhony Brito: 60-Day IL (forearm)
- Joe Musgrove: 60-Day IL (elbow)

Arizona Diamondbacks

- Tyler Locklear: 10-Day IL (elbow)
- Pavin Smith: 60-Day IL (quadricep)
- Lourdes Gurriel Jr.: 10-Day IL (ACL)
- Kevin Ginkel: 60-Day IL (shoulder)
- Tommy Henry: 60-Day IL (elbow)
- Christian Montes De Oca: 60-Day IL (elbow)
- Justin Martinez: 60-Day IL (elbow)
- Cristian Mena: 60-Day IL (shoulder)
- Corbin Burnes: 60-Day IL (elbow)
- A.J. Puk: 60-Day IL (elbow)
- Blake Walston: 60-Day IL (elbow)

In summary

The Arizona Diamondbacks and San Diego Padres wrap up their season series in a crucial NL West matchup at Petco Park. With the Padres holding a 7-5 edge for the year and both teams showcasing strong offensive leaders and pitching matchups, fans can expect high-intensity baseball in optimal weather conditions. As both teams hope for a momentum shift heading into the postseason, this matchup promises action for both die-hard and casual baseball followers.

Related Links

• Arizona Diamondbacks News & Updates
• Arizona Diamondbacks Schedule & Scores
• San Diego Padres News & Updates
• San Diego Padres Schedule & Scores
• MLB News