San Francisco Giants at Chicago White Sox Prediction, Odds - June 29, 2025 MLB

Sunday, June 29th, 2025

San Francisco Giants (45-38, third in the NL West) face the Chicago White Sox (27-56, fifth in the AL Central) in MLB action.

The game is set for Sunday, 2:10 p.m. EDT in Chicago.

The Giants are favored on the moneyline at -156, with the White Sox at +132. The over/under for total runs is set at 8 1/2.

Pitching Probables

Giants: Justin Verlander (0-5, 4.67 ERA, 1.43 WHIP, 52 strikeouts)

White Sox: Jonathan Cannon (0-0)

Game Outlook

This Sunday matchup will decide the three-game series between the Giants and White Sox.

The White Sox hold an 18-24 record at home and are 27-56 overall. They have struggled particularly when allowing home runs, posting a 14-41 record in such games.

San Francisco comes into the game with a 45-38 overall record and a 20-21 mark on the road. The Giants pitching staff ranks third in Major League Baseball with a collective 3.39 ERA.

This is the third meeting between these two teams this season.

Key Players

For the White Sox, Miguel Vargas leads the team with 10 home runs and a .415 slugging percentage. Andrew Benintendi has been performing well recently, going 10 for 40 with four home runs and eight RBI over his last 10 games.

Heliot Ramos is a top performer for the Giants, tallying 16 doubles, a triple, 13 home runs, and 44 RBI. Casey Schmitt has also been hot over the past 10 games, hitting 12 for 33 with a double and two home runs.

Recent Form

Over their last 10 games, the White Sox have a 4-6 record, batting .210 with a 3.40 ERA, and have been outscored by 11 runs.

The Giants also hold a 4-6 record in their last 10 contests, batting .210 with a 4.00 ERA, and have been outscored by nine runs.

Injury Report

White Sox Injuries: Luis Robert (day-to-day, hamstring), Cam Booser (15-Day IL, shoulder), Davis Martin (15-Day IL, forearm), Jared Shuster (15-Day IL, hand), Fraser Ellard (60-Day IL, lat), Ky Bush (60-Day IL, elbow), Miguel Castro (60-Day IL, knee), Jonathan Cannon (15-Day IL, back), Martin Perez (60-Day IL, forearm), Drew Thorpe (60-Day IL, elbow), Prelander Berroa (60-Day IL, elbow), Jesse Scholtens (60-Day IL, elbow)

Giants Injuries: Casey Schmitt (day-to-day, undisclosed), Jerar Encarnacion (10-Day IL, oblique), Matt Chapman (10-Day IL, hand), Tom Murphy (60-Day IL (back)

In summary

The San Francisco Giants (45-38) visit the Chicago White Sox (27-56) on Sunday, June 29, 2025, at 2:10 p.m. EDT to decide their three-game series. The Giants are scheduled to start Justin Verlander (0-5, 4.67 ERA) against White Sox pitcher Jonathan Cannon (0-0). San Francisco is third in the NL West, while Chicago is fifth in the AL Central. Betting odds favor the Giants at -156 with an over/under of 8 1/2 runs. Key players include Miguel Vargas and Andrew Benintendi for the White Sox, and Heliot Ramos and Casey Schmitt for the Giants. Both teams enter the game with a 4-6 record over their last 10 contests.

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