San Francisco Giants vs. St. Louis Cardinals: Preview, Odds, Pitching Matchup & Top Performers for September 5, 2025

Friday, September 5th, 2025

San Francisco Giants vs. St. Louis Cardinals: Game Preview and Key Matchups

The San Francisco Giants look to extend their four-game winning streak as they visit the St. Louis Cardinals at Busch Stadium on Friday night. The Giants currently hold a 71-69 record and sit third in the NL West, while the Cardinals are 70-71 and fourth in the NL Central. Both teams are aiming to gain ground in their respective divisions as the season winds down.

Weather

At Busch Stadium today, expect partly cloudy skies with a high near 82°F, making for comfortable baseball conditions. The chance of precipitation is minimal, so rain delays are unlikely. Winds will be light out of the southeast at 7 mph, which should have little to no impact on gameplay.

Pitching Probables

The starting pitchers for this matchup feature Carson Seymour (0-2, 4.74 ERA, 1.50 WHIP, 18 strikeouts) on the mound for the Giants. The Cardinals will counter with Michael McGreevy (6-2, 4.17 ERA, 1.19 WHIP, 40 strikeouts). With an over/under set at 8.5 runs, and the Cardinals favorited at -118, both pitchers will be critical to their team's success.

Team Overview

The Cardinals have been strong at home this season with a 39-33 record and are especially successful when their offense is firing, boasting a 50-13 record when scoring at least five runs. For the Giants, their road performance remains just above .500 at 36-35, and their pitching staff has delivered a collective 3.79 ERA, ranking sixth in the majors. Notably, this is the first meeting between these two teams in the 2025 season.

Top Performers

For St. Louis, Willson Contreras has been a driving force, tallying 20 home runs, 42 walks, and 78 RBI with a .254 average. Lars Nootbaar remains hot as well, going 11 for 39 with two doubles and a triple in his last 10 games. On the Giants' side, Willy Adames stands out with 18 doubles, two triples, and 26 home runs, while Rafael Devers is on a tear, hitting 15 for 38 with two doubles and five home runs over his last 10 outings.

Recent Results

The Cardinals have gone 6-4 in their last 10 games, posting a .214 batting average and 3.50 ERA, though they've been outscored by four runs over that span. The Giants, meanwhile, are 9-1 in their last 10 contests, boasting an impressive .316 average and outscoring their opponents by 33 runs, despite a 4.50 team ERA.

Injury Report

Cardinals: Alec Burleson (wrist), Yohel Pozo (concussion), John King (back), Brendan Donovan (groin), Nolan Arenado (shoulder), and Zack Thompson (lat) are all on the injured list.

Giants: Randy Rodriguez (elbow), Carson Whisenhunt (back), Landen Roupp (knee), Erik Miller (elbow), Jerar Encarnacion (hamstring), and Tom Murphy (back) are currently sidelined due to injuries.

In summary

The upcoming battle between the San Francisco Giants and the St. Louis Cardinals promises an exciting matchup, with both teams motivated to improve their standings. The Giants bring momentum from a hot streak and solid pitching, while the Cardinals hope to leverage their home-field advantage and potent offense. With favorable weather conditions at Busch Stadium and key players stepping up, this clash is set to be a pivotal moment late in the MLB season.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.