St. Louis Cardinals at Cleveland Guardians Game Preview June 28, 2025

Saturday, June 28th, 2025

St. Louis Cardinals (45-38, third in the NL Central) vs. Cleveland Guardians (40-40, second in the AL Central)

Cleveland; Saturday, 3:10 p.m. EDT

MLB Odds

Guardians -121, Cardinals +100; over/under is 8 1/2 runs

Pitching Probables

Cardinals: Miles Mikolas (4-5, 4.31 ERA, 1.28 WHIP, 51 strikeouts)

Guardians: Slade Cecconi (3-3, 3.38 ERA, 1.29 WHIP, 37 strikeouts)

Bottom Line

The St. Louis Cardinals visit the Cleveland Guardians looking to extend a four-game road winning streak.

Cleveland has gone 20-18 in home games and 40-40 overall. The Guardians have a 24-5 record in games when they scored at least five runs.

St. Louis has gone 19-21 in road games and 45-38 overall. The Cardinals have gone 19-5 in games when they hit at least two home runs.

The teams meet Saturday for the second time this season.

Top Performers

Jose Ramirez leads the Guardians with 30 extra base hits (16 doubles, a triple and 13 home runs). Lane Thomas is 6 for 33 with two home runs and four RBI over the past 10 games.

Brendan Donovan has 21 doubles, five home runs and 29 RBI while hitting .300 for the Cardinals. Alec Burleson is 11 for 40 with three doubles and four home runs over the last 10 games.

Last 10 Games

Guardians: 5-5, .194 batting average, 3.44 ERA, outscored by 11 runs

Cardinals: 7-3, .225 batting average, 3.68 ERA, outscored opponents by seven runs

Injuries

Guardians: Will Brennan: 60-Day IL (forearm), Jose Ramirez: day-to-day (forearm), Andrew Walters: 60-Day IL (lat), Ben Lively: 60-Day IL (forearm), Paul Sewald: 15-Day IL (shoulder), Shane Bieber: 60-Day IL (elbow), Trevor Stephan: 60-Day IL (elbow), John Means: 60-Day IL (elbow), Sam Hentges: 60-Day IL (shoulder)

Cardinals: Jordan Walker: 10-Day IL (appendicitis), Ivan Herrera: 10-Day IL (hamstring), Zack Thompson: 60-Day IL (lat)

In summary

The St. Louis Cardinals (45-38) visit the Cleveland Guardians (40-40) on June 28, 2025, at 3:10 p.m. EDT. The Cardinals are favored at +100, while the Guardians are -121, with an over/under of 8.5 runs. Miles Mikolas pitches for the Cardinals (4-5, 4.31 ERA) against Slade Cecconi for the Guardians (3-3, 3.38 ERA). St. Louis is on a four-game road win streak and has performed well hitting home runs, while Cleveland has a strong home record and is effective when scoring five or more runs. Key players include Jose Ramirez for Cleveland and Brendan Donovan for St. Louis. The Cardinals have been better in their last 10 games (7-3) compared to the Guardians (5-5).

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