St. Louis Cardinals vs. San Francisco Giants: Game Preview, Odds, and Pitching Matchup for September 24, 2025

Wednesday, September 24th, 2025

St. Louis Cardinals vs. San Francisco Giants: Game Preview and Key Matchups

The St. Louis Cardinals travel to Oracle Park to take on the San Francisco Giants in a late September showdown. The Cardinals, standing at 78-80 and fourth in the NL Central, look to continue their strong performance in the season series against the Giants, who are 77-81 and fourth in the NL West.

Pitching Probables

On the mound for St. Louis is Sonny Gray, who holds a 14-8 record with a 4.33 ERA, 1.23 WHIP, and 194 strikeouts. The Giants will counter with JT Brubaker, who has compiled a 0-0 record, 3.65 ERA, 1.22 WHIP, and 18 strikeouts in limited appearances this season.

Weather

At Oracle Park today, expect mostly clear skies with temperatures hovering around the mid-60s, providing ideal baseball conditions. There is little to no chance of precipitation, and a gentle breeze from the west at 7-10 mph may slightly influence fly balls. Fans and players can look forward to a pleasant, comfortable evening at the ballpark.

Team Performances and Recent Trends

The Giants hold a 38-39 record at home and have shown solid power, ranking seventh in the NL with 167 home runs—an average of 1.1 per game. Despite their strong offense, the Giants have struggled over their last ten games, going 2-8 with a .183 batting average and a 5.17 team ERA, being outscored by 18 runs.

The Cardinals have posted a 34-43 road record and their pitchers maintain a collective 4.24 ERA, ranking tenth in the NL. Over their last 10 games, St. Louis has gone 6-4 with a robust .270 batting average and a 3.95 ERA, outscoring opponents by five runs. The Cardinals currently lead the season series between these two teams, 4-1.

Key Players to Watch

For San Francisco, Rafael Devers has powered the offense with 64 extra-base hits—31 doubles and 33 home runs. Heliot Ramos has contributed recently, hitting 8-for-40 with a double, three home runs, and five RBI over the last 10 games. For the Cardinals, Brendan Donovan stands out after his four-hit performance in Tuesday's contest.

Injuries

San Francisco has several players sidelined, including Dominic Smith (hamstring), Randy Rodriguez (elbow), Carson Whisenhunt (back), Landen Roupp (knee), Erik Miller (elbow), and Tom Murphy (back). The Cardinals are also dealing with injuries to Willson Contreras (shoulder), Masyn Winn (meniscus), and Zack Thompson (lat).

In summary

This late-season matchup between the St. Louis Cardinals and San Francisco Giants at Oracle Park features important pitching duels and key player performances amid ideal weather conditions. With the Cardinals holding an edge in the season series and momentum from recent wins, and the Giants looking to bounce back at home, fans can expect an exciting game as both teams wrap up their 2025 MLB campaigns.

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