St. Louis Cardinals vs. Seattle Mariners Prediction, Odds, and Key Players: MLB Game Preview for September 8, 2025

Monday, September 8th, 2025

St. Louis Cardinals vs. Seattle Mariners: Game Preview and Key Insights

The Seattle Mariners will host the St. Louis Cardinals for the first of a three-game series at T-Mobile Park. Both teams are eager to gain ground in their respective divisions, with the Mariners aiming to solidify their position in the AL West and the Cardinals looking to climb the NL Central standings.

Weather

Today at T-Mobile Park, expect partly cloudy skies with temperatures around 70°F—ideal for baseball. There’s little chance of precipitation, and wind will be light out of the northwest at 5-10 mph, making for comfortable playing and viewing conditions at the ballpark.

Team Overviews

St. Louis Cardinals (72-72, fourth in the NL Central) have had a solid record when clubbing multiple home runs, going 27-10 in such games. On the road, however, their performance has dipped slightly with a 31-38 record.

Seattle Mariners (75-68, second in the AL West) have been strong at home, boasting a 41-27 record at T-Mobile Park. Their on-base percentage ranks fifth in the American League at .319, showing offensive consistency throughout the season.

Pitching Probables

The pitching matchup features Miles Mikolas (7-10, 4.89 ERA, 1.33 WHIP, 86 strikeouts) starting for the Cardinals and Bryan Woo (12-7, 3.02 ERA, 0.97 WHIP, 169 strikeouts) on the mound for the Mariners.

Current odds favor the Mariners at -218, with the Cardinals at +179. The over/under is set at 7.5 runs.

Key Players to Watch

For the Mariners, Josh Naylor (.282 batting average, 24 doubles, a triple, and 18 home runs) leads the offense, while Julio Rodriguez is on a hot streak—14-for-41 with five home runs and 16 RBI over his last 10 games.

The Cardinals look to Ivan Herrera (12 doubles, 14 home runs, 55 RBI) and Pedro Pages (6-for-27, a double, two home runs in last 10 games) as offensive contributors.

Recent Performance

Mariners: 4-6 in their last 10 games, with a .263 batting average and a 4.60 ERA, outscoring opponents by eight runs.

Cardinals: 7-3 in their last 10 games, with a .222 batting average and a 3.80 ERA, despite being outscored by three runs.

Injuries

Mariners: Jackson Kowar (shoulder), Trent Thornton (achilles), Logan Evans (elbow), Gregory Santos (knee), and Ryan Bliss (biceps) are on the injured list.

Cardinals: Alec Burleson (wrist), John King (back), Brendan Donovan (groin), Nolan Arenado (shoulder), and Zack Thompson (lat) remain sidelined.

In summary

The Seattle Mariners and St. Louis Cardinals both enter this series hungry for wins as postseason spots are at stake. With strong pitching matchups, key players in form, and favorable weather conditions, fans can expect an exciting start to this three-game set at T-Mobile Park as the Mariners and Cardinals face off for the first time this season.

MLB Schedules

Today's MLB Games

There are no baseball games today.

Tomorrow's MLB Games

There are no baseball games tomorrow.

Yesterday's MLB Games

There were no baseball games yesterday.