Tampa Bay Rays vs. Baltimore Orioles: Game Preview, Odds, Pitching Matchup & Prediction for September 23, 2025

Tuesday, September 23rd, 2025

Tampa Bay Rays vs. Baltimore Orioles: AL East Rivals Clash in Baltimore

The Tampa Bay Rays (76-80, fourth in the AL East) travel to Baltimore to face the Orioles (73-83, fifth in the AL East) as both teams open a pivotal three-game series at Oriole Park at Camden Yards.

Weather

Today at Oriole Park at Camden Yards, expect pleasant baseball weather with temperatures around 72°F under mostly sunny skies. There is little chance of precipitation, and winds will be light at 6 mph out of the southwest, making for ideal playing conditions.

Pitching Matchup

The Rays will send Ryan Pepiot (11-11, 3.77 ERA, 1.16 WHIP, 164 strikeouts) to the mound. The Orioles counter with Dean Kremer (10-10, 4.39 ERA, 1.26 WHIP, 136 strikeouts) in this key divisional battle.

Odds for the matchup favor the Rays at -116, with the Orioles at -104. The over/under is set at 9 runs.

Team Overview

Baltimore enters the series with a 37-41 record at home and sits at 73-83 overall. The Orioles have struggled defensively when surrendering home runs, going 41-67 in those contests.

The Rays, with an overall record of 76-80 and a 35-40 mark on the road, have relied on their disciplined approach at the plate. Tampa Bay batters carry a .314 on-base percentage, ranking eighth in the American League.

This game marks the 11th meeting between the teams this season. The season series is currently tied at 5-5, adding significance to this matchup.

Top Performers to Watch

For Baltimore, Gunnar Henderson leads the offense with a .273 average, 33 doubles, five triples, and 16 home runs. Coby Mayo has been in good form, going 12-for-33 with two homers and four RBIs over the last 10 games.

Tampa Bay’s offense is paced by Junior Caminero, who boasts 28 doubles, 44 homers, and 108 RBIs. Yandy Diaz is 16-for-34 with two doubles, two home runs, and five RBIs in his last 10 games.

Recent Form

Both teams have identical 4-6 records across their last 10 games. The Orioles have struggled at the plate with a .191 average and a 5.00 ERA, while being outscored by 25 runs. The Rays have batted .250 with a 3.50 ERA and have been outscored by two runs over their last 10 contests.

Injury Updates

Baltimore is missing several key players, including Albert Suarez (elbow), Shawn Dubin (elbow), Brandon Young (hamstring), Gary Sanchez (knee), Felix Bautista (shoulder), Zach Eflin (back), Colin Selby (hamstring), and Grayson Rodriguez (elbow).

The Rays also have an extensive injury list, featuring Taylor Walls (groin), Jonny Deluca (hamstring), Brian Van Belle (elbow), Mason Englert (shoulder), Stuart Fairchild (oblique), Jonathan Aranda (wrist), Manuel Rodriguez (forearm), Hunter Bigge (lat), Shane McClanahan (tricep), Alex Faedo (shoulder), and Nathan Lavender (elbow).

In summary

The Tampa Bay Rays and Baltimore Orioles face off in a tightly contested AL East matchup, with both teams aiming to gain ground as the season winds down. With pitching matchups featuring Ryan Pepiot and Dean Kremer, key offensive players ready to make an impact, and pleasant weather ensuring ideal playing conditions, this three-game series opener promises plenty of excitement for fans and is a must-watch for MLB enthusiasts looking for critical late-season action.

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